Repetitive Thoughts and Behavior in Pervasive Developmental Disorders: Treatment with Serotonin Reuptake Inhibitors

Results from two studies indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in children with autism. A study of the selective SRI fluvoxamine found it to be significantl...

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Bibliographic Details
Published inJournal of autism and developmental disorders Vol. 30; no. 5; pp. 427 - 438
Main Authors McDougle, Christopher J, Kresch, Laura E, Posey, David J
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.10.2000
Subjects
Adolescent
Adult
Adults
Antidepressive Agents, Tricyclic - therapeutic use
Anxiety Disorders
Autism
Autistic children
Behavior Disorders
Behavior Problems
Child & adolescent psychiatry
Child Development Disorders, Pervasive - drug therapy
Child, Preschool
Children
Desipramine - therapeutic use
Developmental Disabilities
Drug Therapy
Emotional Disturbances
Female
Followup Studies
Humans
Interpersonal Relationship
Literature reviews
Male
Mental Disorders
Middle Aged
Neuroses
Obsessive compulsive disorder
Outcomes of Treatment
Patients
Pervasive Developmental Disorders
Phenomenology
Program Effectiveness
Psychiatry
Repetitive behaviour
Repetitive thought
Resistance (Psychology)
Self Destructive Behavior
Serotonin
Serotonin reuptake inhibitors
Serotonin Uptake Inhibitors - therapeutic use
Stereotyped Behavior
Thinking
Treatment Outcome
United States > US
Indianapolis Indiana
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Summary:Results from two studies indicate the nonselective serotonin reuptake inhibitor (SRI) clomipramine is more efficacious than the relatively selective norepinephrine reuptake inhibitor desipramine and placebo in children with autism. A study of the selective SRI fluvoxamine found it to be significantly better than placebo for reducing repetitive phenomena and aggression. (Contains references.) (Author/CR)
Bibliography:Special Issue: Treatments for People with Autism and Other Pervasive Developmental Disorders: Research Perspectives.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0162-3257
1573-3432
DOI:10.1023/a:1005551523657