Green synthesis of multifunctional carbon dots from coriander leaves and their potential application as antioxidants, sensors and bioimaging agents

• Published in: Analyst (London) Vol. 140; no. 12; pp. 4260 - 4269
• Main Authors: Sachdev, Abhay, Gopinath, P
• Format: Journal Article
• Language: English
• Published: England 21.06.2015
• Subjects: Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - metabolism; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Biological Transport; Carbon; Carbon - chemistry; Cell Line, Tumor; Chemistry Techniques, Analytical - instrumentation; Chemistry Techniques, Synthetic; Coriandrum - chemistry; Fluorescence; Fourier transforms; Green Chemistry Technology; Humans; Infrared spectroscopy; Molecular Imaging - methods; Nanoparticles; Nanoparticles - chemistry; Nanotechnology - methods; Plant Leaves - chemistry; Scanning electron microscopy; Temperature; Uptakes
• ISSN: 0003-2654; 1364-5528
• DOI: 10.1039/c5an00454c

In the present study, a facile one-step hydrothermal treatment of coriander leaves for preparing carbon dots (CDs) has been reported. Optical and structural properties of the CDs have been extensively studied by UV-visible and fluorescence spectroscopic, microscopic (transmission electron microscopy, scanning electron microscopy) and X-ray diffraction techniques. Surface functionality and composition of the CDs have been illustrated by elemental analysis and Fourier transform infrared spectroscopy (FTIR). Quenching of the fluorescence of the CDs in the presence of metal ions is of prime significance, hence CDs have been used as a fluorescence probe for sensitive and selective detection of Fe(3+) ions. Eventually, biocompatibility and bioimaging aspects of CDs have been evaluated on lung normal (L-132) and cancer (A549) cell lines. Qualitative analysis of cellular uptake of CDs has been pursued through fluorescence microscopy, while quantitative analysis using a flow cytometer provided an insight into the concentration and cell-type dependent uptake of CDs. The article further investigates the antioxidant activity of CDs. Therefore, we have validated the practicality of CDs obtained from a herbal carbon source for versatile applications.