The pathology of chronic asthma

Our understanding of the pathophysiology of asthma has undergone great advances in the past decade, particularly with the recognition of cytokines and the roles they may take in orchestrating the local immune response. With this information, it has been possible to target new therapeutic entities su...

Full description

Saved in:
Bibliographic Details
Published inClinics in chest medicine Vol. 21; no. 2; p. 225
Main Authors Muro, S, Minshall, E M, Hamid, Q A
Format Journal Article
LanguageEnglish
Published United States 01.06.2000
Subjects
Asthma - pathology
Asthma - physiopathology
B-Lymphocytes - physiology
Basophils - physiology
Chronic Disease
Cytokines - physiology
Eosinophils - physiology
Humans
Lymphocyte Activation
Mast Cells - physiology
Neutrophils - physiology
T-Lymphocytes - physiology
Online AccessGet more information

Cover

More Information
Summary:Our understanding of the pathophysiology of asthma has undergone great advances in the past decade, particularly with the recognition of cytokines and the roles they may take in orchestrating the local immune response. With this information, it has been possible to target new therapeutic entities such as cytokine or chemokine receptors. Eosinophils and T lymphocytes have a special place in the inflammatory and structural alterations contributing to the asthmatic diathesis. It is possible that phenotype subsets of these cells exist and they hold the key to perpetuation of immunologic and physiologic abnormalities in asthma.
ISSN:0272-5231
DOI:10.1016/S0272-5231(05)70263-X