Aqueous extract of the Helianthus annuus seed alleviates asthmatic symptoms in vivo
Molecular inflammation is a pivotal process in various degenerative immune diseases, including asthma and atopic dermatitis. In this study, we examined the effects of Helianthus annuus seed (HAS) aqueous extract on an in vivo anti-asthmatic model. Ovalbumin-induced mice were orally administered the...
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Published in | International journal of molecular medicine Vol. 21; no. 1; pp. 57 - 61 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
D.A. Spandidos
01.01.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Molecular inflammation is a pivotal process in various degenerative immune
diseases, including asthma and atopic dermatitis. In this study, we examined the
effects of Helianthus annuus seed (HAS) aqueous extract on an in vivo anti-asthmatic
model. Ovalbumin-induced mice were orally administered the aqueous extract of
Helianthus annuus seeds, and their lungs were assessed by hematoxylin and eosin
staining. Moreover, the expression levels of IL-4/IL-13 cytokines and IgE were
determined. HAS extract induced a decrease in CD4+ cell number, IL-4/IL-13 expression,
and IgE secretion levels in the lungs. Our findings collectively suggest that
the HAS extract has considerable potential in reducing the asthma-like symptoms
induced by a mouse ovalbumin challenge model. However, further isolation and purification
of the extract is required to determine the specific factor(s) responsible for
its anti-asthmatic activity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1107-3756 1791-244X |
DOI: | 10.3892/ijmm.21.1.57 |