Isoprostane levels in lipids extracted from atherosclerotic arteries of nonhuman primates

• Published in: Free radical biology & medicine Vol. 30; no. 12; pp. 1337 - 1346
• Main Authors: Thomas, Michael J, Chen, Qirui, Sorci-Thomas, Mary G, Rudel, Lawrence L
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2001
• Subjects: Animals; Arachidonic Acids - analysis; Arteriosclerosis - metabolism; Atherosclerosis; Cercopithecus aethiops; Cholesterol - analysis; Cholesterol Esters - analysis; Cholesterol, LDL - blood; Diet, Atherogenic; Dietary Fats - pharmacology; Dietary fatty acids; Dinoprost - analysis; F 2-isoprostane; Fatty Acids - pharmacology; Free radical autoxidation; Free Radicals; Iliac Artery - chemistry; Linoleic Acid - administration & dosage; Linoleic Acid - pharmacology; Lipid Peroxidation - drug effects; Lipids; Lipids - chemistry; Oleic Acid - administration & dosage; Oleic Acid - pharmacology; Oxidation-Reduction; Palm Oil; Plant Oils - administration & dosage; Plant Oils - pharmacology; Safflower Oil - administration & dosage; Safflower Oil - pharmacology; DTPA; Free radicals; F 2-isoprostane; PUFA; Dietary fatty acids; MONO; SAT; Lipids; POLY; BHT; LDL; Atherosclerosis; GC; PGF 2α; Free radical autoxidation; GC/MS

Nonhuman primates used in these studies had been fed for 5 years diets enriched with cholesterol and one of three classes of fatty acids: saturated, monounsaturated, or polyunsaturated fatty acids. Atherosclerotic iliac artery lipid extracts were quantitatively analyzed for cholesterol, cholesteryl...