A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis

To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discriminati...

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Published inJournal of rheumatology Vol. 38; no. 12; p. 2598
Main Authors Carmona, F David, Serrano, Aurora, Rodríguez-Rodríguez, Luis, Castañeda, Santos, Miranda-Filloy, José A, Morado, Inmaculada C, Narváez, Javier, Solans, Roser, Sopeña, Bernardo, Marí-Alfonso, Begoña, Unzurrunzaga, Ainhoa, Ortego-Centeno, Norberto, Blanco, Ricardo, de Miguel, Eugenio, Hidalgo-Conde, Ana, Martín, Javier, González-Gay, Miguel A
Format Journal Article
LanguageEnglish
Published Canada 01.12.2011
Subjects
Aged
Biopsy
CD11b Antigen - genetics
Female
Genetic Predisposition to Disease
Genotype
Giant Cell Arteritis - genetics
Giant Cell Arteritis - pathology
Humans
Male
Middle Aged
Polymorphism, Genetic
Spain
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Summary:To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.
ISSN:0315-162X
DOI:10.3899/jrheum.110685