Lipoxins: revelations on resolution
Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that s...
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| Published in | Trends in pharmacological sciences (Regular ed.) Vol. 22; no. 8; pp. 391 - 395 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.08.2001
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from
in vitro and
in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, ‘pro-resolution’ actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed. |
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| AbstractList | Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from
in vitro and
in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, ‘pro-resolution’ actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed. Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, "pro-resolution" actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed. |
| Author | Godson, Catherine Mitchell, Siobhan McMahon, Blaithin Brady, Hugh R. |
| Author_xml | – sequence: 1 givenname: Blaithin surname: McMahon fullname: McMahon, Blaithin organization: Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland – sequence: 2 givenname: Siobhan surname: Mitchell fullname: Mitchell, Siobhan organization: Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland – sequence: 3 givenname: Hugh R. surname: Brady fullname: Brady, Hugh R. organization: Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland – sequence: 4 givenname: Catherine surname: Godson fullname: Godson, Catherine email: cgodson@mater.ie organization: Centre for Molecular Inflammation and Vascular Research, Mater Misericordiae Hospital, Conway Institute of Biomolecular and Biomedical Research, University College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11478982$$D View this record in MEDLINE/PubMed |
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| Keywords | Lipoxins Eicosanoids Laukocyte trafficking Asprin-triggered lipoxins Inflammation Pharmacology |
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| References | Gewirtz (BIB2) 1998; 101 Serhan (BIB11) 2001; 166 Chiang (BIB18) 2000; 191 and attenuate TNF-α-induced chemokine release and colonocyte apoptosis in human intestinal mucosa in press Sodin-Semrl (BIB10) 2000; 164 Takano (BIB12) 1997; 185 Gronert (BIB7) 1998; 187 specifically activates neutrophils through FPRL1/LXA4R and is an agonist for the orphan monocyte–expressed chemoattractant receptor FPRL2. and aspirin-triggered 15-epi-lipoxinA in press MS007769200 Schaldach (BIB22) 1999; 38 Sanak (BIB3) 2000; 16 Hachicha (BIB9) 1999; 189 Maderna (BIB20) 2000; 279 Godson (BIB6) 2000; 164 Savill, Fadok (BIB15) 2000; 407 Munger (BIB13) 1999; 96 Gronert (BIB21) 2001; 158 McMahon (BIB16) 2000; 275 Goh, J. Serhan (BIB1) 1997; 53 Clish (BIB4) 1999; 96 . Christophe, T. Su (BIB17) 1999; 189 (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH Chiang (BIB5) 1999; 104 Bandeira-Melo (BIB14) 2000; 164 antagonize TNF-α-stimulated neutrophil-enterocyte interactions Lipoxin A Munger (10.1016/S0165-6147(00)01771-5_BIB13) 1999; 96 Chiang (10.1016/S0165-6147(00)01771-5_BIB5) 1999; 104 Hachicha (10.1016/S0165-6147(00)01771-5_BIB9) 1999; 189 Chiang (10.1016/S0165-6147(00)01771-5_BIB18) 2000; 191 Sanak (10.1016/S0165-6147(00)01771-5_BIB3) 2000; 16 Serhan (10.1016/S0165-6147(00)01771-5_BIB11) 2001; 166 McMahon (10.1016/S0165-6147(00)01771-5_BIB16) 2000; 275 Schaldach (10.1016/S0165-6147(00)01771-5_BIB22) 1999; 38 Savill (10.1016/S0165-6147(00)01771-5_BIB15) 2000; 407 Su (10.1016/S0165-6147(00)01771-5_BIB17) 1999; 189 Clish (10.1016/S0165-6147(00)01771-5_BIB4) 1999; 96 Godson (10.1016/S0165-6147(00)01771-5_BIB6) 2000; 164 Takano (10.1016/S0165-6147(00)01771-5_BIB12) 1997; 185 Bandeira-Melo (10.1016/S0165-6147(00)01771-5_BIB14) 2000; 164 10.1016/S0165-6147(00)01771-5_BIB19 Sodin-Semrl (10.1016/S0165-6147(00)01771-5_BIB10) 2000; 164 10.1016/S0165-6147(00)01771-5_BIB8 Gewirtz (10.1016/S0165-6147(00)01771-5_BIB2) 1998; 101 Gronert (10.1016/S0165-6147(00)01771-5_BIB7) 1998; 187 Serhan (10.1016/S0165-6147(00)01771-5_BIB1) 1997; 53 Maderna (10.1016/S0165-6147(00)01771-5_BIB20) 2000; 279 Gronert (10.1016/S0165-6147(00)01771-5_BIB21) 2001; 158 |
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| Snippet | Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from
in vitro... Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro... |
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| SubjectTerms | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Asprin-triggered lipoxins Eicosanoids Hydroxyeicosatetraenoic Acids - biosynthesis Hydroxyeicosatetraenoic Acids - metabolism Hydroxyeicosatetraenoic Acids - physiology Inflammation Laukocyte trafficking Lipoxins Structure-Activity Relationship |
| Title | Lipoxins: revelations on resolution |
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