Lipoxins: revelations on resolution

Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that s...

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Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 22; no. 8; pp. 391 - 395
Main Authors McMahon, Blaithin, Mitchell, Siobhan, Brady, Hugh R., Godson, Catherine
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2001
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Asprin-triggered lipoxins
Eicosanoids
Hydroxyeicosatetraenoic Acids - biosynthesis
Hydroxyeicosatetraenoic Acids - metabolism
Hydroxyeicosatetraenoic Acids - physiology
Inflammation
Laukocyte trafficking
Lipoxins
Structure-Activity Relationship
Lipoxins
Eicosanoids
Laukocyte trafficking
Asprin-triggered lipoxins
Inflammation
Pharmacology
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Summary:Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell–cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered 15-epi-LXs can mimic many of the desirable anti-inflammatory, ‘pro-resolution’ actions of native LXs. Given the enhanced stability and efficacy of these compounds a role as novel anti-inflammatory therapeutics is proposed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(00)01771-5