Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta
The endogenous peptides endomorphins 1 and 2 are newly discovered, potent, selective μ-opioid receptor agonists. In the present study, the effects of endomorphins 1 and 2 on vascular smooth muscle tone were investigated on isolated rings from rat aorta with and without endothelium. In rings precontr...
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Published in | Life sciences (1973) Vol. 67; no. 4; pp. 471 - 476 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
16.06.2000
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Subjects | |
Online Access | Get full text |
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Summary: | The endogenous peptides endomorphins 1 and 2 are newly discovered, potent, selective μ-opioid receptor agonists. In the present study, the effects of endomorphins 1 and 2 on vascular smooth muscle tone were investigated on isolated rings from rat aorta with and without endothelium. In rings precontracted with phenylephrine, endomorphins 1 and 2 at concentrations of 0.1 and 1.0 μM, nociceptin at concentrations of 1–100 μM, and adrenomedullin at concentrations of 0.01–1.0 μM induced concentration dependent relaxant responses. The endomorphins and nociceptin were less potent than adrenomedullin. No relaxation was induced by endomorphins 1 and 2 in aortic rings denuded of endothelium and precontracted with phenylephrine. The results of the present studies demonstrate that the endomorphins relax aortic vascular smooth muscle from the rat aorta by an endothelium-dependant mechanism. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/S0024-3205(00)00631-7 |