Application of diagnostic tests in veterinary epidemiologic studies

Important applications of diagnostic tests in non-clinical areas of veterinary medicine include surveillance, monitoring or screening for disease, prevalence estimation, and risk-factor studies. In this review, we address the processing and analysis of diagnostic data with special emphasis on serolo...

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Bibliographic Details
Published inPreventive veterinary medicine Vol. 45; no. 1; pp. 43 - 59
Main Authors Greiner, M, Gardner, I.A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 30.05.2000
Subjects
Animal Diseases - diagnosis
Animal Diseases - epidemiology
Animals
Data Interpretation, Statistical
Diagnostic tests
Diagnostic Tests, Routine - veterinary
Enzyme-Linked Immunosorbent Assay
Epidemiology
Misclassification
Prevalence
Risk Factors
Sensitivity
Sensitivity and Specificity
Specificity
Sensitivity
Specificity
Misclassification
Epidemiology
Diagnostic tests
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Summary:Important applications of diagnostic tests in non-clinical areas of veterinary medicine include surveillance, monitoring or screening for disease, prevalence estimation, and risk-factor studies. In this review, we address the processing and analysis of diagnostic data with special emphasis on serological data from enzyme-linked immunosorbent assays (ELISAs). We describe methods that are used to adjust for misclassification (imperfect sensitivity and specificity) in the different applications of diagnostic tests. These methods often have limitations attributable to the uncertainty of sensitivity and specificity estimates. We review descriptive and analytical statistical methods that allow adequate presentation of non-clinical diagnostic data.
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ObjectType-Review-1
ISSN:0167-5877
1873-1716
DOI:10.1016/S0167-5877(00)00116-1