Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

• Published in: Chinese chemical letters Vol. 24; no. 7; pp. 619 - 621
• Main Authors: Meng, Ying, Wang, Guan, Li, Yue, Hou, Kuan, Yuan, Yue, Zhang, Li-Juan, Song, Hong-Rui, Shi, Wei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.07.2013; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China%Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun 130012, China
• Subjects: Antitumor; HeLa细胞; Pyrrolopyrazinone; Synthesis; 化合物; 合成; 吡嗪酮; 抗肿瘤剂; 抗肿瘤活性; 生物评价; 细胞毒活性; Pyrrolopyrazinone; Synthesis; Antitumor
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2013.04.020

A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.