Immunologic response to infection and its role in septic shock

In summary, the invasion of bacteria across mucosal surfaces is met with a vigorous host response that includes complement, antibody formation (thymus-independent and eventually thymus-dependent), phagocytosis, production of antibacterial peptides and proteins, the production of cytokines that resul...

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Bibliographic Details
Published inCritical care clinics Vol. 16; no. 2; p. 193
Main Author Casey, L C
Format Journal Article
LanguageEnglish
Published United States 01.04.2000
Subjects
Animals
Antibody Formation
Complement Pathway, Alternative - immunology
Cytokines - immunology
Defensins
Epithelium - physiology
Humans
Infection - immunology
Lipopolysaccharides - immunology
Phagocytosis
Proteins
Receptors, Complement
Receptors, Fc
Shock, Septic - immunology
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Summary:In summary, the invasion of bacteria across mucosal surfaces is met with a vigorous host response that includes complement, antibody formation (thymus-independent and eventually thymus-dependent), phagocytosis, production of antibacterial peptides and proteins, the production of cytokines that result in activation of phagocytes and endothelial cells to attract more phagocytes, and the formation of fibrin to limit the spread of infection. The best summary of immune response to infection was written by Lewis Thomas in 1974.
ISSN:0749-0704
DOI:10.1016/S0749-0704(05)70107-X