Cytotoxic terpenes from Abies sibirica

• Published in: Chinese chemical letters Vol. 23; no. 11; pp. 1251 - 1253
• Main Authors: Wang, Gui Rong, Li, Yong Li, Zhang, Wei Dong, Yang, Xian Wen, Liu, Wen Cong, Ye, Ji, Zhu, Zhi Jun, Chen, Hong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2012; School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China%Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China%Department of Pharmacognosy, Jilin Agricultural University, Changchun 130118, China; Department of Pharmacognosy, Jilin Agricultural University, Changchun 130118, China%Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
• Subjects: Abies sibirica; Pinaceae; Terpenes; Triterpene; 光谱数据; 冷杉; 增殖活性; 生物测定; 细胞毒性; 肿瘤细胞; 萜烯; 西伯利亚; Pinaceae; Terpenes; Abies sibirica; Triterpene
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2012.09.013

One new and 16 known compounds were isolated from Abies sibirica. Their structures were assigned mainly on the basis of NMR and MS spectroscopic data. In bioassay for anti-proliferative activity against four human tumor cells, compound 7 exhibited selective anti-proliferative activity against COLO-205 tumor cell with an IC50 value of 0.9 μg/mL.