Characterisation, chromosomal localisation and expression of the mouse Kid3 gene
Kid1 encodes a transcriptional repressor implicated in the differentiation of renal epithelial cells. Here we report the characterisation of Kid3, a novel mouse gene related to Kid1. Kid3 encodes a C 2H 2 zinc finger protein with an N-terminal KRAB transcriptional repression domain. It maps to chrom...
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Published in | Biochimica et biophysica acta Vol. 1490; no. 1; pp. 153 - 158 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
31.01.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Kid1 encodes a transcriptional repressor implicated in the differentiation of renal epithelial cells. Here we report the characterisation of
Kid3, a novel mouse gene related to
Kid1.
Kid3 encodes a C
2H
2 zinc finger protein with an N-terminal KRAB transcriptional repression domain. It maps to chromosome 11, adjacent to
Kid1 and another related gene
Kid2. Northern analysis shows that
Kid3 is highly expressed in embryonic and adult brain, with lower levels in adult and embryonic (E16.5) kidney, gut, lung and heart. Expression of
Kid3 in the kidney is developmentally regulated and suggests a role for
Kid3 in the early stages of nephrogenesis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0167-4781 0006-3002 1879-2634 |
DOI: | 10.1016/S0167-4781(99)00239-0 |