Evaluation of glucose-6-phosphate dehydrogenase activity in two different ethnic groups using a kit employing the haemoglobin normalization procedure

• Published in: Clinical biochemistry Vol. 36; no. 5; pp. 393 - 395
• Main Authors: Reclos, George J., Schulpis, Kleopatra H., Gavrili, Stavroula, Vlachos, George
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2003
• Subjects: Albania - ethnology; Female; G-6-PD; Glucose-6-phosphate dehydrogenase; Glucosephosphate Dehydrogenase - blood; Glucosephosphate Dehydrogenase Deficiency - blood; Glucosephosphate Dehydrogenase Deficiency - ethnology; Greece; Hemoglobin normalization; Hemoglobins - analysis; Humans; Infant, Newborn; Male; Partial G-6-PD deficiency; Profound G-6-PD deficiency; Greece; Albania; Glucose-6-phosphate dehydrogenase; Profound G-6-PD deficiency; G-6-PD; Partial G-6-PD deficiency; Hemoglobin normalization
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/S0009-9120(03)00034-1

Correct evaluation of Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity of two ethnic groups using a fully quantitative kit with a simultaneous Hemoglobin Normalization (Hb Normalization) procedure. Two groups of mothers and their healthy full term newborns of Greek ( n = 1.166) and Albanian ( n = 818) origin were tested for their G-6-PD activity employing a direct normalization protocol. Greek mothers and newborns showed a higher prevalence for G-6-PD deficiency as compared to those of Albanian origin. Males of G-6-PD deficient mothers confirmed the efficacy of the method. A fully quantitative G-6-PD kit employing Hb Normalization is essential for the correct classification of G-6-PD activity, both in male and female subjects.