Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats

Abstract Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but...

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Bibliographic Details
Published inILAR journal Vol. 62; no. 1-2; pp. 133 - 168
Main Authors Helke, Kristi L, Meyerholz, David K, Beck, Amanda P, Burrough, Eric R, Derscheid, Rachel J, Löhr, Christiane, McInnes, Elizabeth F, Scudamore, Cheryl L, Brayton, Cory F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 31.12.2021
Subjects
pathology
bacteria
anatomy
infectious disease
physiology
animal model
spontaneous
virus
neoplasia
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Summary:Abstract Animal models provide a valuable tool and resource for biomedical researchers as they investigate biological processes, disease pathogenesis, novel therapies, and toxicologic studies. Interpretation of animal model data requires knowledge not only of the processes/diseases being studied but also awareness of spontaneous conditions and background lesions in the model that can influence or even confound the study results. Species, breed/stock, sex, age, anatomy, physiology, diseases (noninfectious and infectious), and neoplastic processes are model features that can impact the results as well as study interpretation. Here, we review these features in several common laboratory animal species, including ferret, dog (beagle), pig, sheep, and goats.
ISSN:1084-2020
1930-6180
DOI:10.1093/ilar/ilab005