Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles

• Published in: Journal of magnetism and magnetic materials Vol. 293; no. 1; pp. 605 - 615
• Main Authors: Avilés, Misael O., Ebner, Armin D., Chen, Haitao, Rosengart, Axel J., Kaminski, Michael D., Ritter, James A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2005; Elsevier Science
• Subjects: Blood flow; Circulatory system; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Drug delivery; Exact sciences and technology; High gradient magnetic separation; Magnetic drug targeting; Magnetic implant; Magnetic properties and materials; Magnetic wire; Permanent magnets; Physics; Simulation; Small particles and nanoscale materials; Studies of specific magnetic materials; Magnetic implant; High gradient magnetic separation; Simulation; Model; Drug delivery; Magnetic wire; Circulatory system; Magnetic drug targeting; Blood flow; Magnetic field effects; Ferromagnetic materials; Permanent magnets; Magnetic particles; Wires
• ISSN: 0304-8853
• DOI: 10.1016/j.jmmm.2005.01.089

The use of a ferromagnetic wire implant placed near an artery to assist the collection of magnetic drug carrier particles (MDCPs) using an external magnet is theoretically studied. Three magnetic drug targeting (MDT) systems are evaluated in terms of their MDCP collection efficiency (CE): a permanent magnet and wire is better than a permanent magnet alone, which is better than a homogeneous magnetic field and wire.