Specific uptake of 5-hydroxytryptamine is reduced in lungs from hypoxic pulmonary hypertensive rats

In this study, the aim was to determine whether 5-hydroxytryptamine (5-HT) removal by the pulmonary endothelium is reduced in 1-week hypoxic, pulmonary hypertensive rats by directly measuring [ 3H]5-HT uptake in isolated lungs. In lungs from hypoxic rats, specific 5-HT uptake was reduced. This was d...

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Published inEuropean journal of pharmacology Vol. 396; no. 2; pp. 137 - 140
Main Authors Jeffery, Trina K, Bryan-Lluka, Lesley J, Wanstall, Janet C
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 19.05.2000
Subjects
5-HT (5-hydroxytryptamine, serotonin) uptake
Animals
Carrier Proteins - genetics
Chronic hypoxia
Hypertension, Pulmonary - metabolism
Hypoxia - metabolism
Lung
Lung - metabolism
Male
Membrane Glycoproteins - genetics
Membrane Transport Proteins
Nerve Tissue Proteins
Pulmonary hypertension
rat
Rats
Rats, Wistar
RNA, Messenger - analysis
Serotonin - metabolism
Serotonin Plasma Membrane Transport Proteins
5-HT (5-hydroxytryptamine, serotonin) uptake
Lung
Chronic hypoxia
Pulmonary hypertension
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Summary:In this study, the aim was to determine whether 5-hydroxytryptamine (5-HT) removal by the pulmonary endothelium is reduced in 1-week hypoxic, pulmonary hypertensive rats by directly measuring [ 3H]5-HT uptake in isolated lungs. In lungs from hypoxic rats, specific 5-HT uptake was reduced. This was due to a 50% decrease in the maximal initial rate of uptake rather than a decrease in affinity of 5-HT for its transporter. It is possible that reduced removal of 5-HT may contribute to the elevation in plasma levels of this vasoactive amine in pulmonary hypertension.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(00)00252-1