Emerging trends in high-throughput screening

Novel technologies are emerging for high-throughput screening, driven by the needs and fine-tuning of established drug discovery activities, as well as by the emergence of novel target classes resulting from the deciphering of the human genome. Disciplines other than biology have now entered the scr...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 3; no. 5; pp. 522 - 529
Main Author Entzeroth, Michael
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2003
Subjects
Combinatorial Chemistry Techniques - methods
Combinatorial Chemistry Techniques - trends
Computational Biology - trends
Drug Design
Genome, Human
Genomics - trends
Humans
Ion Channels - chemistry
Magnetic Resonance Spectroscopy
Miniaturization - methods
Pharmaceutical Preparations - chemistry
Technology, Pharmaceutical - trends
CE
NMR
EGF
SAR
HTS
nAChR
GPCR
HPLC
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Summary:Novel technologies are emerging for high-throughput screening, driven by the needs and fine-tuning of established drug discovery activities, as well as by the emergence of novel target classes resulting from the deciphering of the human genome. Disciplines other than biology have now entered the screening scene, as bioinformatics, micro-technology and analytics provide powerful methodologies and applications that were not previously suitable for high-throughput screening. Many of these will move high-throughput screening from a numbers game to a content- and information-based approach to identify leads for novel disease targets.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1471-4892
1471-4973
DOI:10.1016/S1471-4892(03)00088-2