Serological relationships between poxviruses of different genera: Studies with vaccinia virus and myxoma virus

The serological relationships between vaccinia virus (an Orthopoxvirus) and myxoma virus (a Leporipoxvirus) were investigated by the techniques of micro-immunodiffusion and virus neutralization. Immunodiffusion tests demonstrated clear-cut but relatively minor cross-reactivity between the soluble an...

Full description

Saved in:
Bibliographic Details
Published inJournal of comparative pathology Vol. 91; no. 4; pp. 493 - 502
Main Author Alcock, S.R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.1981
Subjects
animal diseases
animal health
Animals
Antigens, Viral - analysis
Cell Line
Chick Embryo
Cross Reactions
Epitopes
Immunodiffusion
Kidney
Mice
myxoma virus
Myxoma virus - immunology
Neutralization Tests
Rabbits
Skin - microbiology
Solubility
vaccinia virus
Vaccinia virus - immunology
viral diseases of animals and humans
Online AccessGet full text

Cover

More Information
Summary:The serological relationships between vaccinia virus (an Orthopoxvirus) and myxoma virus (a Leporipoxvirus) were investigated by the techniques of micro-immunodiffusion and virus neutralization. Immunodiffusion tests demonstrated clear-cut but relatively minor cross-reactivity between the soluble antigens of the two viruses. The cross-reacting fraction of myxoma soluble antigen showed no serological relationship to vaccinia N.P. antigen. The results of virus neutralization tests were equivocal. Results of immunodiffusion tests varied greatly with antigen concentration and other technical factors, and it is suggested that such variation may explain the conflicting data obtained in previous comparative studies with soluble antigens of different poxvirus genera.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0021-9975
1532-3129
DOI:10.1016/0021-9975(81)90077-3