Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH®, Chiralcel OJ-R® and Chirobiotic-T™® phases

This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH®), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R®) and teicoplanin (Chirobiotic T™®) phases. All columns showed good chiral recognitio...

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Published inJournal of biochemical and biophysical methods Vol. 53; no. 1; pp. 15 - 24
Main Authors Visegrády, Balázs, Konecsni, Tünde, Grobuschek, Nina, Schmid, Martin G, Kilár, Ferenc, Aboul-Enein, Hassan Y, Gübitz, Gerald
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.10.2002
Subjects
Benzoates
Benzothiadiazines
Carbamates
Cellulose - analogs & derivatives
Cellulose-based stationary phase
Chromatography, High Pressure Liquid - instrumentation
Chromatography, High Pressure Liquid - methods
Diuretics
Enantiomer separation
Equipment Design
Phenylcarbamates
Reproducibility of Results
Sensitivity and Specificity
Sodium Chloride Symporter Inhibitors - chemistry
Sodium Chloride Symporter Inhibitors - isolation & purification
Stereoisomerism
Teicoplanin
Teicoplanin chiral stationary phase
Cellulose-based stationary phase
Diuretics
Teicoplanin chiral stationary phase
Enantiomer separation
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Abstract This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH®), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R®) and teicoplanin (Chirobiotic T™®) phases. All columns showed good chiral recognition ability for this class of compounds. Out of seven compounds investigated, six were resolved with baseline resolution with at least one of the three columns.
AbstractList This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH®), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R®) and teicoplanin (Chirobiotic T™®) phases. All columns showed good chiral recognition ability for this class of compounds. Out of seven compounds investigated, six were resolved with baseline resolution with at least one of the three columns.
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out of seven compounds investigated, six were resolved with baseline resolution with at least one of the three columns.
Author Konecsni, Tünde
Grobuschek, Nina
Kilár, Ferenc
Schmid, Martin G
Aboul-Enein, Hassan Y
Gübitz, Gerald
Visegrády, Balázs
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  givenname: Gerald
  surname: Gübitz
  fullname: Gübitz, Gerald
  email: gerald.guebitz@kfunigraz.ac.at
  organization: Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl-Franzens University Graz, Universitätsplatz 1, A-8010 Graz, Austria
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crossref_primary_10_1002_chir_22690
crossref_primary_10_1080_15422110701826997
crossref_primary_10_1016_j_chroma_2014_06_084
crossref_primary_10_1016_j_jbbm_2007_09_007
crossref_primary_10_1080_00032719_2013_814058
Cites_doi 10.1007/BF02687754
10.1002/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO;2-5
10.1016/S0021-9673(00)00941-9
10.1246/bcsj.68.3289
10.1021/ja00330a057
10.1016/0021-9673(94)00789-C
10.1016/S0021-9673(00)00501-X
10.1021/ac00081a019
10.1002/chir.530070614
10.1016/0021-9673(94)80400-1
10.1021/ja960050x
10.1016/S0021-9673(00)00946-8
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Keywords Cellulose-based stationary phase
Diuretics
Teicoplanin chiral stationary phase
Enantiomer separation
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Snippet This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel...
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SubjectTerms Benzoates
Benzothiadiazines
Carbamates
Cellulose - analogs & derivatives
Cellulose-based stationary phase
Chromatography, High Pressure Liquid - instrumentation
Chromatography, High Pressure Liquid - methods
Diuretics
Enantiomer separation
Equipment Design
Phenylcarbamates
Reproducibility of Results
Sensitivity and Specificity
Sodium Chloride Symporter Inhibitors - chemistry
Sodium Chloride Symporter Inhibitors - isolation & purification
Stereoisomerism
Teicoplanin
Teicoplanin chiral stationary phase
Title Chiral separation of thiazide diuretics by HPLC on Chiralcel OD-RH®, Chiralcel OJ-R® and Chirobiotic-T™® phases
URI https://dx.doi.org/10.1016/S0165-022X(02)00088-X
https://www.ncbi.nlm.nih.gov/pubmed/12406582
https://search.proquest.com/docview/72631125
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