Cervical light-induced fluorescence in humans decreases throughout gestation and before delivery: Preliminary observations
Objective: The purpose of this study was to investigate gestational changes of cervical light-induced fluorescence, an index of cross-linked collagen, and the relationship between light-induced fluorescence and the time-to-delivery interval. Study design: Fifty patients were included in one of two g...
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Published in | American journal of obstetrics and gynecology Vol. 188; no. 2; pp. 537 - 541 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Philadelphia, PA
Elsevier Inc
01.02.2003
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Objective: The purpose of this study was to investigate gestational changes of cervical light-induced fluorescence, an index of cross-linked collagen, and the relationship between light-induced fluorescence and the time-to-delivery interval. Study design: Fifty patients were included in one of two groups. (1) Twenty-one healthy pregnant women without signs of labor underwent repeated cervical light-induced fluorescence measurement during the last trimester. (2) Light-induced fluorescence was measured in 29 patients with signs of labor, and the time from measurement to delivery was noted. Cervical light-induced fluorescence was obtained noninvasively with a prototype instrument that was designed specifically for this purpose. Spearman correlation and the Student t test and receiver-operator characteristics analysis were performed (P < .05). Results: Light-induced fluorescence correlated negatively with gestational age and positively with time-to-delivery interval, was significantly lower in patients who were delivered <24 hours compared with those patients who were delivered >24 hours later, and was predictive of delivery within 24 hours. Conclusion: Cervical light-induced fluorescence decreases significantly as gestational age increases. Light-induced fluorescence may be a useful tool to identify patients in whom delivery is imminent. (Am J Obstet Gynecol 2003;188:537-41.) |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-9378 1097-6868 |
DOI: | 10.1067/mob.2003.94 |