Evidence for collagen fibrils inside the cells of granular cell myoblastomas

An electron microscope study was performed on two cases of subcutaneous granular cell myoblastomas. Phosphotungstic acid staining reveals the intracellular formation of collagen fibrils both inside the granules and scattered outside them, but always in relation with ribosomes or ergastoplasmic sacs....

Full description

Saved in:
Bibliographic Details
Published inPathology, research and practice Vol. 170; no. 1-3; p. 61
Main Authors Costanzi, G, Bosincu, L, Denti, S, Pittaluga, S, Sanna, E
Format Journal Article
LanguageEnglish
Published Germany 01.12.1980
Subjects
Adolescent
Child
Collagen - analysis
Coloring Agents
Female
Fibroblasts - chemistry
Granular Cell Tumor - chemistry
Granular Cell Tumor - ultrastructure
Humans
Male
Microscopy, Electron
Phosphotungstic Acid
Shoulder
Soft Tissue Neoplasms - chemistry
Soft Tissue Neoplasms - ultrastructure
Staining and Labeling - methods
Online AccessGet more information

Cover

More Information
Summary:An electron microscope study was performed on two cases of subcutaneous granular cell myoblastomas. Phosphotungstic acid staining reveals the intracellular formation of collagen fibrils both inside the granules and scattered outside them, but always in relation with ribosomes or ergastoplasmic sacs. Pericellular deposition of basal-membrane-like material is a constant feature; however it appears to be more a precollagen material, extruded by cells, than a true basal membrane. This observation strongly supports the view that granular cells in Abrikossoff tumors are fibroblasts of muscle (and nerve?) sheaths abnormally producing precollagen material.
ISSN:0344-0338
DOI:10.1016/S0344-0338(80)80156-7