Effects of the naturally-occurring chemosensitizer malagashanine and its combination with chloroquine on KB and P388 cell lines and isolated auricle

Besides the determination of its LD 50 value, the cytotoxicity against KB and P388 cell lines and the toxicity on isolated guinea pig auricle of malagashanine and its combination with chloroquine were assessed. Malagashanine alone was devoid of cytotoxicity and cardiac effect on isolated auricle, an...

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Published inPhytomedicine (Stuttgart) Vol. 6; no. 5; pp. 331 - 334
Main Authors Ramanitrahasimbola, D., Ratsimamanga-Urverg, S., Rasoanaivo, P., Rakoto-Ratsimamanga, A.
Format Journal Article
LanguageEnglish
Published Germany Elsevier GmbH 01.11.1999
Subjects
Alkaloids - toxicity
Animals
Chemosensitizer
Chloroquine - toxicity
Cytotoxicity
Drug Synergism
Female
Guinea Pigs
Heart Atria - drug effects
Heart toxicity
Inhibitory Concentration 50
Lethal Dose 50
Malagashanine
Mice
Strycbnos myrtoides
Tumor Cells, Cultured
Strycbnos myrtoides
Cytotoxicity
Malagashanine
Chemosensitizer
Heart toxicity
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Summary:Besides the determination of its LD 50 value, the cytotoxicity against KB and P388 cell lines and the toxicity on isolated guinea pig auricle of malagashanine and its combination with chloroquine were assessed. Malagashanine alone was devoid of cytotoxicity and cardiac effect on isolated auricle, and importantly, when combined to chloroquine, did not affect the inherent toxicity and cardiac toxicity of this antimalarial agent.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(99)80054-3