Baseline K + channels as targets of general anesthetics: studies of the action of volatile anesthetics on TOK1

A large body of evidence has accumulated in recent years pointing towards the GABA A receptor as a primary determinant of volatile anesthetic action ( Franks and Lieb, 1994). Nevertheless, our understanding of the function of the central nervous system (CNS) remains sufficiently incomplete that othe...

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Bibliographic Details
Published inToxicology letters Vol. 100; pp. 293 - 300
Main Authors Spencer Yost, C, Gray, Andrew T, Winegar, Bruce D, Leonoudakis, Dmitri
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 23.11.1998
Subjects
Anesthetics, General - pharmacology
Animals
General anesthetic
Humans
K + channels
Neurons - drug effects
Neurons - metabolism
Potassium Channels - drug effects
Saccharomyces cerevisiae Proteins
TOK1
Volatile anesthetic
Volatile anesthetic
K + channels
General anesthetic
TOK1
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Summary:A large body of evidence has accumulated in recent years pointing towards the GABA A receptor as a primary determinant of volatile anesthetic action ( Franks and Lieb, 1994). Nevertheless, our understanding of the function of the central nervous system (CNS) remains sufficiently incomplete that other mechanisms of CNS depression remain to be examined. We have studied a new family of potassium (K +) channels which function as regulators of the baseline excitability of neuronal tissue. As such they must be considered potential targets for volatile anesthetic action and as a possible mechanism by which volatile anesthetics act to allow patients to undergo noxious surgical stimulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0378-4274
1879-3169
DOI:10.1016/S0378-4274(98)00198-2