Relation between Severity of Injury and the Early Activation of Interleukins in Multiple-Injured Patients

• Published in: European surgical research Vol. 37; no. 6; pp. 360 - 364
• Main Authors: Yagmur, Y., Ozturk, H., Unaldi, M., Gedik, E.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.11.2005; S. Karger AG
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; APACHE; Biological and medical sciences; Case-Control Studies; Child; Child, Preschool; Female; General aspects; Glasgow Coma Scale; Humans; Injury Severity Score; Interleukins - blood; Male; Medical sciences; Middle Aged; Original Paper; Prognosis; Prospective Studies; Trauma Severity Indices; Turkey - epidemiology; Wounds and Injuries - immunology; Wounds and Injuries - mortality; Turkey; Cytokines; Mortality; Multiple-injured patients; Human; Multiple; Interleukin; Cytokine; Patient; Activation; Severity; Medicine; Anesthesia; Early; Lesion; Resuscitation; Multiple-injured patients ,Cytokines ,Μortality
• ISSN: 0014-312X; 1421-9921
• DOI: 10.1159/000090337

The aim of this study was to evaluate the relation between severity of injury and the early activation of interleukins in multiple-injured patients. Ninety-nine patients with multiple injuries were included in this prospective study. Plasma levels of interleukin (IL)-1, IL-2, IL-6, IL-8 and TNF-α were measured. Injury Severity Score (ISS), Revised Trauma Score (RTS), Glasgow Coma Score (GCS) and the Acute Physiology and Chronic Health Evaluation II (APACHE-II) were all recorded. Of the 99 patients, 82 were male and 17 were female. The mean age was 26.6 ± 20.7 years. The mortality rate for this series was 17%. Patients who died from trauma exhibited a significant increase for IL-2, IL-6 and IL-8 in comparison with patients who survived. Significant differences for ISS, RTS and GCS were found between survivors and non-survivors. Values in all patients with ISS >16 were increased and these increases were significant for IL-6 and IL-2. These data show that the initial increase of IL-2, IL-6 and IL-8 might predict the patients with a high possibility of mortality and a significant increase of IL-2 and IL-6 in patients with ISS >16 might be used in a new developed trauma score combined with ISS as an indicator for the injury severity.