Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria

Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its...

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Published inBiochimie Vol. 85; no. 7; pp. 651 - 657
Main Authors Cubillos, Marcia, Alba, Martha Patricia, Bermúdez, Adriana, Trujillo, Mary, Patarroyo, Manuel Elkin
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.07.2003
Subjects
Amino Acid Sequence
Animals
Antigens, Protozoan - blood
Antigens, Protozoan - chemistry
Antigens, Protozoan - immunology
Aotus
Aotus trivirgatus
Magnetic Resonance Spectroscopy
Malaria
Malaria - prevention & control
Molecular Sequence Data
Peptide Fragments - chemistry
Peptides
Peptides - chemistry
Peptides - immunology
Plasmodium falciparum
Plasmodium falciparum - chemistry
Protein Conformation
SERA protein
serine repeat antigen
Structure
Structure-Activity Relationship
Vaccine
SERA protein
Vaccine
Malaria
Peptides
Structure
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Summary:Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides’ secondary structure and their function as immunogen against malaria.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0300-9084
1638-6183
DOI:10.1016/S0300-9084(03)00136-6