Plasmodium falciparum SERA protein peptide analogues having short helical regions induce protection against malaria
Three Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in Aotus monkeys, whilst native peptide 6737 and its...
Saved in:
Published in | Biochimie Vol. 85; no. 7; pp. 651 - 657 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
France
Elsevier Masson SAS
01.07.2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Three
Plasmodium falciparum serine repeat antigen (SERA) protein peptides were studied by NMR and structure calculations being done in 70:30 water:trifluoroethanol solution. Peptide 22834 was shown to be immunogenic and protective against malaria in
Aotus monkeys, whilst native peptide 6737 and its analogue 14096 did not present protection against the disease in these monkeys. Results showed a relationship between these peptides’ secondary structure and their function as immunogen against malaria. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0300-9084 1638-6183 |
DOI: | 10.1016/S0300-9084(03)00136-6 |