Biosynthesis of sulphur amino acids in Saccharomyces cerevisiae: regulatory roles of methionine and S-adenosylmethionine reassessed

cys4-1, a mutation in the reverse trans-sulphuration pathway, relieves the sulphate assimilation pathway and homocysteine synthase from methionine-mediated repression. Since the mutation blocks the synthesis of cysteine from methionine downstream from homocysteine, this indicates that neither methio...

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Bibliographic Details
Published inCurrent genetics Vol. 22; no. 4; p. 273
Main Authors Paszewski, A. (Polish Academy of Sciences, Warszawa (Poland). Inst. of Biochemistry and Biophysics), Ono, B.I
Format Journal Article
LanguageEnglish
Published United States 01.10.1992
Subjects
ACIDE AMINE
AMINO ACIDS
Amino Acids, Sulfur - biosynthesis
AMINOACIDOS
AZUFRE
BIOSINTESIS
BIOSYNTHESE
BIOSYNTHESIS
Carbon-Oxygen Lyases
Cysteine Synthase
EFECTORES MOLECULARES
EFFECTEUR MOLECULAIRE
EFFECTORS
Enzyme Repression
Gene Expression Regulation, Fungal
Lyases - metabolism
METHIONINE
Methionine - metabolism
METIONINA
Multienzyme Complexes
PHYSIOLOGICAL REGULATION
REGULACION FISIOLOGICA
REGULATION PHYSIOLOGIQUE
Regulatory effector
S-Adenosylmethionine - metabolism
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins
SOUFRE
SULPHUR
Sulphur amino acid
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Summary:cys4-1, a mutation in the reverse trans-sulphuration pathway, relieves the sulphate assimilation pathway and homocysteine synthase from methionine-mediated repression. Since the mutation blocks the synthesis of cysteine from methionine downstream from homocysteine, this indicates that neither methionine nor S-adenosylmethionine serve as low-molecular-mass effectors in this regulatory system, contradicting earlier hypotheses.
Bibliography:F30
93B0533
ISSN:0172-8083
1432-0983
DOI:10.1007/BF00317920