Oral Microbiota and Pediatric Asthma Phenotype: A New Window for Biomarkers?

Ghedin and Huang discuss the study by Abdel-Aziz et al analyzing the microbiota of oropharyngeal swabs collected from 241 children recruited with mild, moderate, or severe school-age asthma or preschool wheezing as part of a multicenter European observational cohort study (U-BIOPRED [Unbiased Biomar...

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Published inAmerican journal of respiratory and critical care medicine Vol. 208; no. 2; pp. 119 - 121
Main Authors Ghedin, Elodie, Huang, Yvonne J.
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 15.07.2023
Subjects
Asthma
Asthma - diagnosis
Asthma - immunology
Biomarkers
Children & youth
Genotype & phenotype
Humans
Hypersensitivity
Microbiota
Microbiota - immunology
Pediatrics
Phenotype
Transcriptome
Online AccessGet full text

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Abstract Ghedin and Huang discuss the study by Abdel-Aziz et al analyzing the microbiota of oropharyngeal swabs collected from 241 children recruited with mild, moderate, or severe school-age asthma or preschool wheezing as part of a multicenter European observational cohort study (U-BIOPRED [Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes]). The authors hypothesized that although no differences in microbial diversity were previously found to be associated with disease severity in this dataset, there could be compositional differences that correlate with clinically relevant phenotypes.
AbstractList Ghedin and Huang discuss the study by Abdel-Aziz et al analyzing the microbiota of oropharyngeal swabs collected from 241 children recruited with mild, moderate, or severe school-age asthma or preschool wheezing as part of a multicenter European observational cohort study (U-BIOPRED [Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes]). The authors hypothesized that although no differences in microbial diversity were previously found to be associated with disease severity in this dataset, there could be compositional differences that correlate with clinically relevant phenotypes.
Author Ghedin, Elodie
Huang, Yvonne J.
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10.1126/scitranslmed.aab2271
10.1164/rccm.202211-2107OC
10.1038/s41467-017-02573-2
10.1183/13993003.00731-2021
10.1136/thx.2006.063487
10.5588/ijtld.22.1010
10.1038/emm.2015.91
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References bib14
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Abdel-Aziz MI (bib9) 2023; 208
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StartPage 119
SubjectTerms Asthma
Asthma - diagnosis
Asthma - immunology
Biomarkers
Children & youth
Genotype & phenotype
Humans
Hypersensitivity
Microbiota
Microbiota - immunology
Pediatrics
Phenotype
Transcriptome
Title Oral Microbiota and Pediatric Asthma Phenotype: A New Window for Biomarkers?
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