The induction of oxidative stress and cellular death by the drinking water disinfection by-products, dichloroacetate and trichloroacetate in J774.A1 cells

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 135; no. 2; pp. 119 - 128
• Main Authors: Hassoun, Ezdihar A, Ray, Sunetra
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2003
• Subjects: Animals; Cell Death - drug effects; Cell Line; Cellular viability; Dichloroacetate; Dichloroacetic Acid - administration & dosage; Dichloroacetic Acid - pharmacology; Disinfection; Dose-Response Relationship, Drug; J774.A1 macrophages; Lactate dehydrogenase (LDH); Oxidative stress; Oxidative Stress - drug effects; Superoxide anion; Superoxide dismutase; Trichloroacetate; Trichloroacetic Acid - administration & dosage; Trichloroacetic Acid - pharmacology; Water purification by-products; Water Supply; Dichloroacetate; Trichloroacetate; Oxidative stress; Superoxide anion; Lactate dehydrogenase (LDH); J774.A1 macrophages; Superoxide dismutase; Water purification by-products; Cellular viability

The in vitro toxicity of the drinking water disinfection by products dichloroacetate (DCA) and trichloroacetate (TCA) were studied using the J774A.1 macrophage cell line. DCA and TCA were added to cell cultures at concentrations ranging between 8–32 mM and incubated for 24, 36 and 60 h. DCA and TCA...