Concise synthesis of （-）-anisomycin

The antibiotic （-）-anisomycin was synthesized starting from D-tyrosine using Sharpless asymmetric epoxidation as a key reaction followed by formation and hydrolysis of oxazoline set up all chiral center.

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Bibliographic Details
Published inChinese chemical letters Vol. 23; no. 6; pp. 647 - 649
Main Authors Li, Ji, Feng, Yan Hua, Li, Xin Bai, Han, Wei, Liu, Huan Qiu, Shao, Guo Guang
Format Journal Article
LanguageEnglish
Published NEW YORK Elsevier B.V 01.06.2012
Elsevier
Department of Anesthesiology, The First Hospital of Jilin University Changchun 130021, China%Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun 130021, China
Subjects
Anisomycin
Chemistry
Chemistry, Multidisciplinary
d-Tyrosine
Oxazoline
Physical Sciences
Science & Technology
Sharpless asymmetric epoxidation
不对称
手性中心
抗生素
氧化合成
茴香
酪氨酸
Anisomycin
Oxazoline
Sharpless asymmetric epoxidation
d-Tyrosine
D-Tyrosine
CELLS
INHIBITORS
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Summary:The antibiotic （-）-anisomycin was synthesized starting from D-tyrosine using Sharpless asymmetric epoxidation as a key reaction followed by formation and hydrolysis of oxazoline set up all chiral center.
Bibliography:Anisomycin; D-Tyrosine; Sharpless asymmetric epoxidation; Oxazoline
The antibiotic （-）-anisomycin was synthesized starting from D-tyrosine using Sharpless asymmetric epoxidation as a key reaction followed by formation and hydrolysis of oxazoline set up all chiral center.
11-2710/O6
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2012.03.029