Oxidative modification of serum albumin in an experimental glycation model of diabetes mellitus in vitro: Effect of the pyridoindole antioxidant stobadine

• Published in: Life sciences (1973) Vol. 65; no. 18; pp. 1995 - 1997
• Main Authors: Stefek, M., Krizanova, L., Trnkova, Z.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.10.1999
• Subjects: Animals; antioxidant; Antioxidants - chemistry; Carbolines - chemistry; diabetic complications; Fluorescence; Glycosylation; Oxidation-Reduction; protein glyco-oxidation; Serum Albumin, Bovine - chemistry; stobadine; diabetic complications; antioxidant; protein glyco-oxidation; stobadine

Under conditions of an experimental in vitro glycation model, the pyridoindole antioxidant stobadine significantly inhibited glycation-related fluorescence changes of bovine serum albumin as well as the yield of 2,4-dinitrophenyl-hydrazine-reactive carbonyls with an efficacy comparable to that of th...