The association between typhoid carriage, typhoid infection and subsequent cancer at a number of sites

It has been demonstrated that bacteria can produce the very potent carcinogens (N-nitroso compounds), from nitrite and suitable amines. It has been hypothesized that this can happen whenever a body site which is normally sterile becomes colonized by bacteria. If this is so then such chronic infectio...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of cancer prevention Vol. 4; no. 2; p. 187
Main Authors Caygill, C P, Braddick, M, Hill, M J, Knowles, R L, Sharp, J C
Format Journal Article
LanguageEnglish
Published England 01.04.1995
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Carrier State - epidemiology
Child
Child, Preschool
Cohort Studies
Disease Outbreaks
Female
Humans
Infant
Male
Middle Aged
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - mortality
Risk Factors
Scotland - epidemiology
Sex Factors
Typhoid Fever - complications
Typhoid Fever - epidemiology
Scotland
Online AccessGet more information

Cover

More Information
Summary:It has been demonstrated that bacteria can produce the very potent carcinogens (N-nitroso compounds), from nitrite and suitable amines. It has been hypothesized that this can happen whenever a body site which is normally sterile becomes colonized by bacteria. If this is so then such chronic infections should result in an increased incidence of local cancers and also of cancers at some distant sites. To test this we studied the risk of cancer at various sites in a cohort of chronic carriers of Salmonella typhi/paratyphi. We have observed a greatly increased risk of cancers of the biliary tract and also of cancers of the colorectum, pancreas, lung and all sites. The results are discussed in terms of the hypothesis being tested.
ISSN:0959-8278
DOI:10.1097/00008469-199504000-00010