Chemical profile and toxicogenetic safety assessment of Smallanthus sonchifolius (yacon) organic extracts

The interest in Smallanthus sonchifolius (yacon) has strongly resurfaced due to its multiple beneficial effects on human health. This study aimed at determining the toxicity and the chemical profile of an ethanol extract (EE) and a crude lactone mixture (CLM) of yacon leaves. Cytotoxicity and genoto...

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Bibliographic Details
Published inNatural product research Vol. 37; no. 22; pp. 3868 - 3872
Main Authors Moreira Szokalo, Rocío Ayelén, Ulloa, Jerónimo, Tulino, María Soledad, Redko, Flavia, Flor, Sabrina, Muschietti, Liliana, Carballo, Marta A.
Format Journal Article
LanguageEnglish
Published Abingdon Taylor & Francis Ltd 17.11.2023
Subjects
Bioassays
Cell viability
Comet assay
Cytotoxicity
Ethanol
Genotoxicity
Lactones
Sesquiterpene lactones
Smallanthus sonchifolius
Solvents
Spectroscopy
Statistical analysis
Toxicity
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Summary:The interest in Smallanthus sonchifolius (yacon) has strongly resurfaced due to its multiple beneficial effects on human health. This study aimed at determining the toxicity and the chemical profile of an ethanol extract (EE) and a crude lactone mixture (CLM) of yacon leaves. Cytotoxicity and genotoxicity tests were performed by the MTT assay and the alkaline version of the comet assay respectively. The phytochemical analysis, performed by chromatographic and spectroscopy techniques, revealed the presence of nine sesquiterpene lactones (STLs) and two acyclic diterpene acids. In all cases, cell viability was inversely proportional to the extract concentration employed. The effects obtained with the highest dose of EE were significantly different from those obtained with the negative and solvent controls. Conversely, no significant differences were observed between the lowest doses of EE and controls. As for CLM, all tested doses showed statistically significant increases, as compared to negative and solvent controls.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2022.2153361