Immune dysfunction in trauma

This article documents that all immunomodulation strategies for patients sustaining traumatic injury are still under intense investigation. Although we can speculate that combination strategies may be more beneficial than single-agent immunomodulation approaches, comprehensive clinical studies are r...

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Bibliographic Details
Published inThe Surgical clinics of North America Vol. 79; no. 6; p. 1385
Main Authors Napolitano, L M, Faist, E, Wichmann, M W, Coimbra, R
Format Journal Article
LanguageEnglish
Published United States 01.12.1999
Subjects
Adjuvants, Immunologic - therapeutic use
Critical Illness
Humans
Immunity, Cellular - immunology
Immunologic Factors - immunology
Nutritional Support
Sepsis - prevention & control
Wounds and Injuries - immunology
Wounds and Injuries - therapy
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Summary:This article documents that all immunomodulation strategies for patients sustaining traumatic injury are still under intense investigation. Although we can speculate that combination strategies may be more beneficial than single-agent immunomodulation approaches, comprehensive clinical studies are required to determine efficacious immune therapy for trauma patients. The only strategy available to clinicians caring for trauma patients is immunonutrition, and this should be strongly considered as a rational approach to improve immune function and reduce septic complications in critically ill or injured patients.
ISSN:0039-6109
DOI:10.1016/S0039-6109(05)70084-0