Naringenin degradation by the endophytic diazotroph Herbaspirillum seropedicae SmR1

Several bacteria are able to degrade flavonoids either to use them as carbon sources or as a detoxification mechanism. Degradation pathways have been proposed for several bacteria, but the genes responsible are not known. We identified in the genome of the endophyte Herbaspirillum seropedicae SmR1 a...

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Published inMicrobiology (Society for General Microbiology) Vol. 159; no. Pt 1; pp. 167 - 175
Main Authors Marin, A M, Souza, E M, Pedrosa, F O, Souza, L M, Sassaki, G L, Baura, V A, Yates, M G, Wassem, R, Monteiro, R A
Format Journal Article
LanguageEnglish
Published England 01.01.2013
Subjects
Bacterial Proteins - genetics
Biotransformation
Flavanones - metabolism
Flavonoids - metabolism
Gene Expression Regulation, Bacterial - drug effects
Gene Knockout Techniques
Herbaspirillum - genetics
Herbaspirillum - metabolism
Operon
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Summary:Several bacteria are able to degrade flavonoids either to use them as carbon sources or as a detoxification mechanism. Degradation pathways have been proposed for several bacteria, but the genes responsible are not known. We identified in the genome of the endophyte Herbaspirillum seropedicae SmR1 an operon potentially associated with the degradation of aromatic compounds. We show that this operon is involved in naringenin degradation and that its expression is induced by naringenin and chrysin, two closely related flavonoids. Mutation of fdeA, the first gene of the operon, and fdeR, its transcriptional activator, abolished the ability of H. seropedicae to degrade naringenin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1350-0872
1465-2080
DOI:10.1099/mic.0.061135-0