Comparison of Sm complexes with Sn compounds for syntheses of copolymers composed of lactide and ε-caprolactone and their biodegradabilities

• Published in: Reactive & functional polymers Vol. 61; no. 2; pp. 277 - 292
• Main Authors: Yasuda, Hajime, Yamamoto, Katsuhiro, Nakayama, Yuushou, Tsutsumi, Chikara, Lecomte, Philippe, Jerome, Robert, McCarthy, Stephan, Kaplan, David
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.09.2004; Elsevier Science
• Subjects: Applied sciences; Biocompatibility; Biodegradability; Compost; Copolymerization; Exact sciences and technology; Organic polymers; Physicochemistry of polymers; Poly(LA-b-CL); Poly(LA-b-CL-b-LA); Poly(LA-ran-CL); Polyesters; Preparation, kinetics, thermodynamics, mechanism and catalysts; Proteinase K; Rare earth metal complex; Tin compound; Compost; Biodegradability; Poly(LA-b-CL-b-LA); Rare earth metal complex; Proteinase K; Poly(LA-b-CL); Tin compound; Polyesters; Biocompatibility; Copolymerization; Poly(LA-ran-CL); Lanthanide Organic compounds; Biological properties; Lactone copolymer; Lactic acid copolymer; Mechanical properties; Samarium Organic compounds; Experimental study; Complex catalyst copolymerization; Samarium complex; Random copolymer; Triblock copolymer; Caprolactone copolymer; Diblock copolymer; Enzymatic digestion; Tin Organic compounds; Ring opening copolymerization; Comparative study; Aliphatic copolymer
• ISSN: 1381-5148
• DOI: 10.1016/j.reactfunctpolym.2004.06.007

The comparison of organolanthanide complexes, (C 5Me 5) 2SmMe(THF) (Sm1) and [(C 5Me 5) 2Sm] 2(PhCCCCPh) (Sm2), with tin compounds, Bu 2Sn(OMe) 2 (Sn1) and Bu 2Sn(OCH 2CH 2CH 2O) (Sn2), in the preparation of random and diblock copolymers composed of l-lactide ( l-LA) or d,l-LA and ε-caprolactone (CL), and the preparation of triblock copolymers composed of l-LA/CL/ l-LA was studied and the biodegradabilities of the resulting copolymers with proteinase K and a compost were examined. Poly( l-LA- ran-CL) shows much higher degradability than poly( l-LA) with proteinase K, and poly( l-LA), poly( l-LA- ran-CL) and poly( l-LA- b-CL) ( b means block) prepared with Sm1 had better degradability than those synthesized with the Sn1 compound. The degradability of poly( l-LA- ran-CL) with proteinase K is higher than that of poly( l-LA- b-CL). Poly(LA- ran-CL) and poly(LA- b-CL) prepared with Sm1 revealed higher degradability than those obtained with Sn1 using a compost. Triblock copolymers, poly( l-LA- b-CL- b- l-LA), synthesized with Sm2 revealed nearly the same degradability with those obtained with Sn2 using a compost. Finally, biocompatibility was studied with macrophage activation assay using RAW 264.7, and metabolic viability assay using Cell Titer Aqueous non-radioactive Cell.