Preparation of imprinted monolithic column under molecular crowding conditions

Molecular crowding is a new concept to obtain molecularly imprinted polymers（MIPs） with greater capacity and selectivity.In this work,molecular crowding agent was firstly applied to the preparation of MIPs monolithic column.A new polymerization system based on molecular crowding surrounding was deve...

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Bibliographic Details
Published inChinese chemical letters Vol. 22; no. 8; pp. 989 - 992
Main Authors Li, Xiao Xia, Liu, Xin, Bai, Li Hong, Duan, Hong Quan, Huang, Yan Ping, Liu, Zhao Sheng
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2011
College of Pharmacy, Tianjin Medical University, Tianjin 300070, China%College of Pharmacy, Tianjin Medical University, Tianjin 300070, China
Basic Medical Research Centre of Tianjin, Tianjin Medical University, Tianjin 300070, China
Subjects
Enrofloxacin
MIPS
Molecular crowding
Molecularly imprinted polymer
Monolithic column
分子印迹聚合物
制备
四氢呋喃
恩诺沙星
挤条
整体柱
聚苯乙烯
Molecular crowding
Molecularly imprinted polymer
Enrofloxacin
Monolithic column
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Summary:Molecular crowding is a new concept to obtain molecularly imprinted polymers（MIPs） with greater capacity and selectivity.In this work,molecular crowding agent was firstly applied to the preparation of MIPs monolithic column.A new polymerization system based on molecular crowding surrounding was developed to prepare enrofloxacin-imprinted monolith,which was composed of polystyrene and tetrahydrofuran.The result showed that the monolithic MIPs under molecular crowding conditions presented good molecular recognition for enrofloxacin with an imprinting factor of 3.03.
Bibliography:Molecular crowding is a new concept to obtain molecularly imprinted polymers（MIPs） with greater capacity and selectivity.In this work,molecular crowding agent was firstly applied to the preparation of MIPs monolithic column.A new polymerization system based on molecular crowding surrounding was developed to prepare enrofloxacin-imprinted monolith,which was composed of polystyrene and tetrahydrofuran.The result showed that the monolithic MIPs under molecular crowding conditions presented good molecular recognition for enrofloxacin with an imprinting factor of 3.03.
11-2710/O6
Xiao Xia Li,Xin Liu,Li Hong Bai,Hong Quan Duan, Yan Ping Huang,Zhao Sheng Liu a College of Pharmacy,Tianjin Medical University,Tianjin 300070,China b Basic Medical Research Centre of Tianjin,Tianjin Medical University,Tianjin 300070,China
Molecularly imprinted polymer; Monolithic column; Enrofloxacin; Molecular crowding
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2011.04.010