Polycations. 17. Synthesis and properties of polycationic derivatives of carbohydrates

• Published in: Carbohydrate research Vol. 344; no. 13; pp. 1620 - 1627
• Main Authors: Thomas, Marie, Montenegro, Diego, Castaño, Alejandra, Friedman, Laura, Leb, Jay, Huang, Mia Lace, Rothman, Leah, Lee, Heidi, Capodiferro, Craig, Ambinder, Daniel, Cere, Eva, Galante, Jessica, Rizzo, JaimeLee, Melkonian, Karin, Engel, Robert
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 08.09.2009; Elsevier
• Subjects: Alditol derivatives; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial; Bacteria - drug effects; Biochemistry & Molecular Biology; Carbohydrate Sequence; Carbohydrates - chemical synthesis; Carbohydrates - chemistry; Carbohydrates - pharmacology; Cationic carbohydrates; Chemistry; Chemistry, Applied; Chemistry, Organic; Gels; Glucosides - chemistry; Life Sciences & Biomedicine; Lipids; Microbial Sensitivity Tests; Molecular Structure; Physical Sciences; Salts; Science & Technology; Sugar Alcohols - chemistry; Alditol derivatives; Lipids; Salts; Antibacterial; Cationic carbohydrates; STRINGS; PEPTIDES; SURFACES
• ISSN: 0008-6215; 1873-426X
• DOI: 10.1016/j.carres.2009.04.021

In our continuing investigation of polycationic salts for purposes of antimicrobial action, ion-channel blocking, and construction of ionic liquids, we have prepared several series of polycationic salts derived from carbohydrate precursors. These salts are currently being investigated for optimal efficacy as antibacterials and antifungals, as well as for other applications. The syntheses of such series of salts are described here along with preliminary antibacterial testing results and a discussion of their properties indicating their potential utility for several purposes.