Revisions to the Xenopus gastrula fate map: Implications for mesoderm induction and patterning

A revised fate map of the gastrula Xenopus embryo predicts the existence of patterning mechanisms that operate within the animal/vegetal axis of the mesoderm‐forming marginal zone. We review here molecular and embryologic data that demonstrate that such mechanisms are present and that they operate i...

Full description

Saved in:
Bibliographic Details
Published inDevelopmental dynamics Vol. 225; no. 4; pp. 409 - 421
Main Authors Kumano, Gaku, Smith, William C.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.12.2002
Subjects
animal/vegetal
Animals
blood
Body Patterning
Cell Lineage
fibroblast growth factor
Fibroblast Growth Factors - metabolism
Gastrula - physiology
Gene Expression Regulation, Developmental
induction
MAP Kinase Signaling System
mesoderm
Mesoderm - metabolism
Mesoderm - physiology
Models, Biological
Organizers, Embryonic - physiology
patterning
Signal Transduction
three‐signal model
Time Factors
Xenopus
Xenopus - embryology
Online AccessGet full text

Cover

More Information
Summary:A revised fate map of the gastrula Xenopus embryo predicts the existence of patterning mechanisms that operate within the animal/vegetal axis of the mesoderm‐forming marginal zone. We review here molecular and embryologic data that demonstrate that such mechanisms are present and that they operate independently of the Spemann organizer. Evidence suggests that polarized fibroblast growth factor activity in the animal/vegetal axis patterns this axis. We present a model of mesoderm induction and patterning that integrates the new data on Spemann organizer‐independent animal/vegetal patterning with data on other inductive pathways known to act on the gastrula marginal zone. © 2002 Wiley‐Liss, Inc.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.10177