CK2 signaling in androgen-dependent and -independent prostate cancer

• Published in: Journal of cellular biochemistry Vol. 99; no. 2; pp. 382 - 391
• Main Authors: Wang, Guixia, Ahmad, Kashif A., Unger, Gretchen, Slaton, Joel W., Ahmed, Khalil
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2006
• Subjects: androgen; Androgens - metabolism; Animals; Apoptosis; cancer; Casein Kinase II - metabolism; Cell Line, Tumor; Cell Proliferation; chromatin; CK2 (formerly casein kinase 2); growth factors; Humans; Male; Models, Biological; Neoplasms, Hormone-Dependent - metabolism; Neoplasms, Hormone-Dependent - pathology; nuclear matrix; prostate; Prostate - metabolism; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Signal Transduction; signaling
• ISSN: 0730-2312; 1097-4644
• DOI: 10.1002/jcb.20847

Protein serine/threonine kinase casein kinase 2 (CK2) is a key player in cell growth and proliferation but is also a potent suppressor of apoptosis. CK2 has been found to be dysregulated in all the cancers that have been examined, including prostate cancer. Investigations of CK2 signaling in the prostate were originally initiated in this laboratory, and these studies have identified significant functional activities of CK2 in relation to normal prostate growth and to the pathobiology of androgen‐dependent and ‐independent prostate cancer. We present a brief overview of these developments in the context of prostate biology. An important outcome of these studies is the emerging concept that CK2 can be effectively targeted for cancer therapy. J. Cell. Biochem. 99: 382–391, 2006. © 2006 Wiley‐Liss, Inc.