Pediatric thyroid cancer arising after treatment for pleuropulmonary blastoma

• Published in: Pediatric blood & cancer Vol. 50; no. 4; pp. 901 - 902
• Main Authors: Oue, Takaharu, Inoue, Masami, Kubota, Akio, Kuwae, Yuko, Kawa, Keisei
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2008
• Subjects: Adenocarcinoma, Follicular - pathology; Adenocarcinoma, Follicular - therapy; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; bone marrow transplantation; Child, Preschool; children; Female; Humans; Iodine Radioisotopes - therapeutic use; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - therapy; Pleural Neoplasms - drug therapy; Pleural Neoplasms - pathology; pleuropulmonary blastoma; Pulmonary Blastoma - drug therapy; Pulmonary Blastoma - pathology; Pulmonary Surgical Procedures; thyroid carcinoma; Thyroid Neoplasms - pathology; Thyroid Neoplasms - therapy
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.21265

A 3‐year‐old female presented with a large tumor occupying the right thoracic space. Open biopsy revealed the pathological diagnosis of pleuropulmonary blastoma. After the first‐line chemotherapy, the patient underwent surgical resection, then two courses of high‐dose chemotherapy. Three years later, follicular carcinoma of the right thyroid lobe was found, so a right hemithyroidectomy was performed. Five months later, the thyroid tumor recurred. The remaining thyroid lobe was completely excised and radioiodine therapy was administered. The patient has remained tumor‐free for 3 years. The etiology and treatment of the uncommon combination of pleuropulmonary blastoma and thyroid carcinoma is discussed. Pediatr Blood Cancer 2008;50:901–902. © 2007 Wiley‐Liss, Inc.