Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes

• Published in: British journal of nutrition Vol. 99; no. 3; pp. 511 - 519
• Main Authors: Nuttall, Frank Q., Schweim, Kelly, Hoover, Heidi, Gannon, Mary C.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.03.2008
• Subjects: administration & dosage; Aged; Biological and medical sciences; blood; blood glucose; Blood Glucose - metabolism; Body Weight; Cross-Over Studies; Design; Diabetes; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - physiopathology; Diet; diet therapy; Diet, Diabetic; dietary carbohydrate; Dietary Carbohydrates; Dietary Carbohydrates - administration & dosage; dietary fat; Dietary Fats; Dietary Fats - administration & dosage; dietary protein; Dietary Proteins; Dietary Proteins - administration & dosage; fasting; Fasting - blood; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glycaemic index; Glycated Hemoglobin; Glycated Hemoglobin A - metabolism; glycemic index; Glycohaemoglobin; glycohemoglobin; Heart failure; High-protein diet; Human subjects; Humans; hyperglycemia; Insulin; Kidney diseases; LoBAG30 diet; Male; Mathematical analysis; men; metabolism; Middle Aged; Minority & ethnic groups; noninsulin-dependent diabetes mellitus; Nutrition; Nutrition research; physiopathology; Postprandial Period; postprandial state; Sample variance; special diets; Thyroid diseases; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Glycaemic index; Insulin; High-protein diet; Glycohaemoglobin; Endocrinopathy; Type 2 diabetes; Pancreatic hormone; High-protein diet: Glycaemic index: Glycohaemoglobin: Insulin; Metabolic diseases; Index; Glucose; Protein; Blood; Feeding; Vertebrata; Mammalia; Diet
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114507819155

In subjects with untreated type 2 diabetes, we previously determined that a weight-maintenance, non-ketogenic diet containing 30 % protein, 50 % fat and 20 % carbohydrate (30:50:20) decreased the percentage total glycohaemoglobin (%tGHb) by 2·2 % glycohaemoglobin over 5 weeks compared to a diet recommended for the American public (protein–fat–carbohydrate 15:30:55). Both the fasting and postprandial glucose were decreased. The objective of the present study was to determine if increasing the carbohydrate content from 20 to 30 % at the expense of fat would still provide a similar effect on %tGHb, fasting and postprandial glucose concentration. Eight men with untreated type 2 diabetes were studied over a 5-week period. Results at the beginning (standard diet) and end of the 5-week study were analysed. Body weight was stable. Fasting glucose concentration decreased by 40 %; 24 h glucose area response decreased by 45 %. Insulin did not change. Mean %tGHb decreased by 1·7 (from 10·8 to 9·1 %), and was still decreasing linearly at 5 weeks. In conclusion, a high-protein, 30 % carbohydrate diet could be a patient-empowering method of improving the hyperglycaemia of type 2 diabetes without pharmacologic intervention. Long-term effects and general applicability of this diet remain to be determined.