Conformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbone

The solution three‐dimensional structure of pseudopentasaccharide 6, which constitutes the product from the GPI‐PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics...

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Bibliographic Details
Published inEuropean Journal of Organic Chemistry Vol. 2005; no. 16; pp. 3489 - 3498
Main Authors Chevalier, Franck, Lopez-Prados, Javier, Perez, Serge, Martín-Lomas, Manuel, Nieto, Pedro M.
Format Book Review Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.08.2005
WILEY‐VCH Verlag
Wiley-VCH Verlag
Subjects
Conformational analysis/ Molecular flexibility/ Molecular modelling
GPI anchor
NMR spectroscopy
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Summary:The solution three‐dimensional structure of pseudopentasaccharide 6, which constitutes the product from the GPI‐PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics study with explicit water molecules and a full NMR analysis study of intramolecular hydrogen bonding in solution. The results indicate that 6 exists in an extended conformation with a considerable flexibility compatible with a hinge‐like conformational motion. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Bibliography:ark:/67375/WNG-K28TG7QF-H
ArticleID:EJOC200500171
istex:EF52647901CD9A09042FEB341C60EB920A629C81
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.200500171