A Microwave-Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines

• Published in: European Journal of Organic Chemistry Vol. 2007; no. 1; pp. 201 - 208
• Main Authors: Declerck, Valérie, Ribière, Patrice, Nédellec, Yannig, Allouchi, Hassan, Martinez, Jean, Lamaty, Frédéric
• Format: Book Review Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.01.2007; WILEY‐VCH Verlag; Wiley; Wiley-VCH Verlag
• Subjects: Chemical Sciences; Chemistry; Chemistry, Organic; Microwaves; Nanoparticles; Nitrogen heterocycles; Organic chemistry; Palladium; Physical Sciences; Science & Technology; Solvent effects; microwaves; POLYMER-SUPPORTED SYNTHESIS; ORGANIC-SYNTHESIS; solvent effects; IONIC LIQUID; PALLADIUM NANOPARTICLES; nanoparticles; SOLVENT-FREE; nitrogen heterocycles; COUPLING REACTION; palladium; RECYCLABLE CATALYST; POLYETHYLENE-GLYCOL; LIQUID-PHASE SYNTHESIS; PROMOTED EFFICIENT SYNTHESIS

The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with...