A Microwave-Assisted Heck Reaction in Poly(ethylene glycol) for the Synthesis of Benzazepines
The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with...
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Published in | European Journal of Organic Chemistry Vol. 2007; no. 1; pp. 201 - 208 |
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Main Authors | , , , , , |
Format | Book Review Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
01.01.2007
WILEY‐VCH Verlag Wiley Wiley-VCH Verlag |
Subjects | |
Online Access | Get full text |
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Summary: | The Heck reaction of alkylated 2‐(trimethylsilyl)ethanesulfonyl (SES)‐protected β‐amino esters provides benzazepines in good yields. Good selectivity towards cyclisation was obtained when the reaction was performed in PEG 3400 as the solvent under microwave activation. Cleavage of the SES group with HF provides the corresponding free benzazepine. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007) |
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Bibliography: | istex:E1D9B00ACE032D7618D4A08689CF0EB6F6AAB7D4 ark:/67375/WNG-G573GLJH-M ArticleID:EJOC200600680 CNRS MENRT |
ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.200600680 |