Lymphomatosis cerebri showing transient spontaneous regression

We describe the case of a 35‐year‐old man who presented with a seizure. Brain magnetic resonance imaging showed multiple white matter lesions in the cerebral hemispheres. His seizure was controllable with antiepileptics, and he remained asymptomatic for the next 4 months with follow‐up magnetic reso...

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Published inNeurology and clinical neuroscience Vol. 5; no. 3; pp. 93 - 95
Main Authors Inamasu, Joji, Nishimoto, Masaaki, Kitamura, Yohei, Mayanagi, Keita, Nakatsukasa, Masashi, Yoshii, Masami, Oshima, Takeo, Tomiyasu, Kazuhiro
Format Journal Article
LanguageEnglish
Published Tokyo Wiley Subscription Services, Inc 01.05.2017
Subjects
Atrophy
B-cell lymphoma
Biopsy
Central nervous system
Cerebral hemispheres
Cognitive ability
leukoencephalopathy
Lymphocytes B
Lymphoma
lymphomatosis cerebri
Magnetic resonance imaging
Metastases
multiple sclerosis
Neuroimaging
NMR
Nuclear magnetic resonance
spontaneous regression
Substantia alba
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Summary:We describe the case of a 35‐year‐old man who presented with a seizure. Brain magnetic resonance imaging showed multiple white matter lesions in the cerebral hemispheres. His seizure was controllable with antiepileptics, and he remained asymptomatic for the next 4 months with follow‐up magnetic resonance imaging showing transient spontaneous regression. However, he developed progressive decline in cognitive functions approximately 1 year after symptom onset. Magnetic resonance imaging showed recurrence of the white matter lesions and progression of brain atrophy. A brain biopsy established the pathological diagnosis of diffuse large B‐cell lymphoma, and he was clinically diagnosed with lymphomatosis cerebri. Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma characterized by diffuse infiltration of lymphomatous cells into the brain without forming a cohesive tumor mass. Although the clinical and radiographic course is rapidly progressive in the great majority of patients with lymphomatosis cerebri, transient spontaneous regression can occur, posing diagnostic challenges for physicians.
ISSN:2049-4173
2049-4173
DOI:10.1111/ncn3.12120