Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

• Published in: Circulation (New York, N.Y.) Vol. 140; no. 14; pp. 1205 - 1216
• Main Authors: Tian, Rong, Colucci, Wilson S, Arany, Zoltan, Bachschmid, Markus M, Ballinger, Scott W, Boudina, Sihem, Bruce, James E, Busija, David W, Dikalov, Sergey, Dorn, Gerald W, Galis, Zorina S, Gottlieb, Roberta A, Kelly, Daniel P, Kitsis, Richard N, Kohr, Mark J, Levy, Daniel, Lewandowski, E Douglas, McClung, Joseph M, Mochly-Rosen, Daria, O’Brien, Kevin D, O’Rourke, Brian, Park, Joon-Young, Ping, Peipei, Sack, Michael N, Sheu, Shey-Shing, Shi, Yang, Shiva, Sruti, Wallace, Douglas C, Weiss, Robert G, Vernon, Hilary J, Wong, Renee, Longacre, Lisa Schwartz, Shi, Scarlet
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 01.10.2019
• Subjects: Biomedical Research - methods; Biomedical Research - trends; Cardiovascular System - pathology; Education - methods; Education - trends; Heart Failure - diagnosis; Heart Failure - epidemiology; Heart Failure - therapy; Humans; Mitochondria - physiology; National Heart, Lung, and Blood Institute (U.S.) - trends; Research Report - trends; Translational Research, Biomedical - methods; Translational Research, Biomedical - trends; United States - epidemiology; United States; heart failure; mitochondria; cardiovascular diseases
• ISSN: 0009-7322; 1524-4539; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.119.040551

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.