Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2

• Published in: Bioorganic & medicinal chemistry Vol. 17; no. 13; pp. 4290 - 4295
• Main Authors: PAULINO, Niraldo, CARVALHO RODRIGUES, Naiara, CELSO PARDI, Paulo, PABLO QUINCOCES SUAREZ, José Agustín, DOS SANTOS, Reginaldo Pereira, SCREMIN, Amarilis, VOGEL, Christian, FEIST, Holger, MICHALIK, Dirk
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 01.07.2009
• Subjects: Analgesics; Analgesics - chemical synthesis; Analgesics - pharmacology; Analgesics - therapeutic use; Animals; Anisoles - chemical synthesis; Anisoles - pharmacology; Anisoles - therapeutic use; Anti-Inflammatory Agents - chemical synthesis; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Cell Line; Cell Survival - drug effects; Dinoprostone - metabolism; Edema - chemically induced; Edema - drug therapy; Inflammation - chemically induced; Inflammation - drug therapy; Ketones - chemical synthesis; Ketones - pharmacology; Ketones - therapeutic use; Male; Medical sciences; Mice; Neuropharmacology; NF-kappa B - metabolism; Nitric Oxide - metabolism; Pain - chemically induced; Pain - drug therapy; Pharmacology. Drug treatments; Oedema; Prostaglandin E2; Dienone; Pentadienone; Prostaglandin E; Chemical synthesis; Peritonitis; Edema; Monocyte; Arachidonic acid derivatives; Rodentia; Antiinflammatory agent; Polyunsaturated fatty acid; RAW 264.7; Ketone; In vitro; Biological activity; In vivo; Vertebrata; Mammalia; Analgesic; Cell line; Mouse; Animal; Nitric oxide; Anti-inflammatory
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2009.05.034

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E(2) production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.