Growth factors and hematopoietic stem cells

The hematopoietic system is mediated in part by cell-to-cell interactions and soluble mediators or growth factors (cytokines). A large number of cytokines directly and potently control hematopoietic stem and precursor cell proliferation and differentiation. This review focuses on the recent studies...

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Bibliographic Details
Published inHematology/oncology clinics of North America Vol. 11; no. 6; p. 1173
Main Authors Veiby, O P, Mikhail, A A, Snodgrass, H R
Format Journal Article
LanguageEnglish
Published United States 01.12.1997
Subjects
Animals
Colony-Stimulating Factors
Growth Substances
Hematopoietic Stem Cells
Humans
Interleukins
Stem Cell Factor
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Summary:The hematopoietic system is mediated in part by cell-to-cell interactions and soluble mediators or growth factors (cytokines). A large number of cytokines directly and potently control hematopoietic stem and precursor cell proliferation and differentiation. This review focuses on the recent studies devoted to the role of cytokines in the ex vivo expansion and differentiation of hematopoietic stem and precursor cells.
ISSN:0889-8588
DOI:10.1016/S0889-8588(05)70487-1